Bioinformatics Data Manager

23/05/2021, 23:55

Genetics and Epidemiology
Translational Genetics
Full time
Fixed Term
2 years
The Institute of Cancer Research, London, is one of the world’s most influential cancer research institutes, with an outstanding record of achievement dating back more than 100 years. We provided the first convincing evidence that DNA damage is the basic cause of cancer, laying the foundation for the now universally accepted idea that cancer is a genetic disease. Today, The Institute of Cancer Research (ICR) leads the world at isolating cancer-related genes and discovering new targeted drugs for personalised cancer treatment.

Under the leadership of our Chief Executive, Professor Paul Workman FRS, the ICR is ranked as the UK’s leading academic research centre. Together with our partner The Royal Marsden, we are rated in the top five cancer centres globally.

The ICR is committed to attracting, developing and retaining the best minds in the world to join us in our mission – to make the discoveries that defeat cancer.

A Bioinformatics Data Manager is required to work with us on delivery of our £4.3 million CRUK Catalyst Award: “CanGene CanVar: Data Resources, Clinical and Educational Tools to leverage Cancer Susceptibility Genetics for Early Detection and Prevention of Cancer”, running 2019-2024 (

This large program has been designed to produce research and resources that will improve how we deliver national NHS testing for cancer susceptibility genes such as BRCA1, BRCA2 and Lynch Syndrome genes. It will involve working with a large team of scientists, clinicians and patients highly passionate about achieving this goal.

We are seeking an individual with an exceptional track-record in managing large-scale genomic and related datasets, with sound skills in core informatics and coding, exceptional organisational skills, and an interest in and understanding of the genetics and genomics of cancer.

The role will comprise sourcing, importing, quality-checking and maintaining high-quality datasets, including:

  • Genetic/genomic data generated inhouse, such as SNP array and Next-Generation Sequencing data
  • Data retrieved from public repositories such as ClinVar and gnomAD
  • Running and maintaining scripts written in R, Python and Bash
  • Running pipelining software such as NextFlow

There may also be the opportunity for the post holder to undertake their own analytical projects and contribute more broadly to conceptualisation, project management, write-up and delivery.

The post will be situated at ICR Sutton within the Division of Genetic and Epidemiology in the laboratory of Professors Clare Turnbull and Richard Houlston FRS, which comprises 25-30 post-doctoral scientists, bioinformaticians and students involved in a range of projects relating to Cancer Genomics.

For the right candidate, we are very open to flexible daily/weekly work-patterns, including part-time/part-home working. Occasional UK/international travel may be required.

More details are available within the job description and person specification.

To apply please submit the online application on the ICR Careers site, attaching your CV with the supporting statement (addressing with specific examples where you meet the person specification, a brief description of your relevant experience and incl. the names and addresses of at least two referees).

Informal enquiries are welcome and can be made to Professor Clare Turnbull by emailing Please note – this address is for enquiries only and applications must be submitted on-line, via the e-recruitment system.


We consider all applications on merit and have a strong commitment to enhancing the diversity of our staff.

The ICR is the leading academic research centre in the UK. Effective industry collaboration and innovation in new medicines and technologies are at the heart of our approach to drive benefits for patients. The ICR is ranked:


  • first for the quality and impact of our research*
  • second worldwide for the number of our publications cited in patents**
  • fourth worldwide for the citation rate of scientific research published across all fields**
  • fourth worldwide for top-cited research publications**
  • in the top five higher education institutions worldwide for academic influence and commercial impact**


*2014 Research Excellence Framework

** U-Multirank, 2020

Funded by

Cancer Research UK
Additional Documentation for Candidates