Bioinformatics Officer in Tumour Heterogeneity and Drug Resistance

16/02/2020, 23:55

Molecular Pathology
Evolutionary Genomics & Modelling
Full time
Fixed Term
3 years
£32,000 - £44,400
The Institute of Cancer Research, London, is one of the world’s most influential cancer research institutes, with an outstanding record of achievement dating back more than 100 years. We provided the first convincing evidence that DNA damage is the basic cause of cancer, laying the foundation for the now universally accepted idea that cancer is a genetic disease. Today, The Institute of Cancer Research (ICR) leads the world at isolating cancer-related genes and discovering new targeted drugs for personalised cancer treatment.

Under the leadership of our Chief Executive, Professor Paul Workman FRS, the ICR is ranked as the UK’s leading academic research centre. Together with our partner The Royal Marsden, we are rated in the top five cancer centres globally.

The ICR is committed to attracting, developing and retaining the best minds in the world to join us in our mission – to make the discoveries that defeat cancer.

The new Centre for Evolution and Cancer within the Institute of Cancer Research is supported by a Strategic Award from the Wellcome Trust. We focus on interrogating clonal evolution in tumours by studying the dynamics of heterogeneous cancer cell populations and their microenvironment. We make use of multi-region genomic profiling, single-cell genetics, computational histopathological analysis and mathematical modelling to reconstruct the past evolutionary history of tumours and predict their future. 

Prof Andrea Sottoriva is the Deputy Director of the Centre for Evolution and Cancer and his lab focuses on deciphering the dynamics of cancer growth, progression and treatment resistance in each patient using a combination of cancer genomic approaches, experimental model systems and mathematical analyses, with the objective of predicting the future course of the disease.

For this position, we are seeking a highly motivated Bioinformatics Officer with expertise in bioinformatics analysis of cancer genomic data. The successful candidate will be responsible for the analysis of longitudinal multi-omics data from patient circulating tumour DNA and from experimental model systems, and for the interpretation of the data in light of tumour heterogeneity and cancer evolution. The candidate must have a solid background in bioinformatics and computational biology, and experience with cancer genomic datasets. The successful candidate will work closely with a diverse team to formulate and validate hypotheses. 

Applicants should have a good first degree in computer science, physics, engineering, biological sciences, statistics or similar subject. A PhD in computational biology or equivalent is desirable. Excellent organizational and communication skills are essential. 

Appointment will be on a Fixed Term Contract for 3 years in the first instance. The salary for the post will be dependent on candidate skills and experience, the full salary range for Analytical Scientist 2 grade is £32,000 to £44,400. Appointments are normally made at the start of the range which represents the market rate for the. Future progression is based on annual performance review.

Informal enquiries can be made to Dr Andrea Sottoriva ( Please DO NOT send your application via email, formal applications must be submitted online on 

To apply please upload your CV and complete an online application form addressing in the Supporting Statement section how you meet the person specification and including the names and addresses of two referees.

If you are an EU citizen please see the below link for further information about Brexit:


We consider all applications on merit and have a strong commitment to enhancing the diversity of our staff.

In partnership with

Additional Documentation for Candidates

This Program is closed to applications.