Higher Scientific Officer / Scientific Officer

The new Centre for Evolution and Cancer within the Institute of Cancer Research is supported by a Strategic Award from the Wellcome Trust. We focus on interrogating clonal evolution in tumours by studying the dynamics of heterogeneous cancer cell populations and their microenvironment. We make use of multi-region genomic profiling, single-cell genetics, computational histopathological analysis and mathematical modelling to reconstruct the past evolutionary history of tumours and predict their future.

Prof Andrea Sottoriva is the Deputy Director of the Centre for Evolution and Cancer and his lab focuses on deciphering the dynamics of cancer growth, progression and treatment resistance in each patient using a combination of cancer genomic approaches, experimental model systems and mathematical analyses, with the objective of anticipating the future course of the disease.

We tackle cancer as a complex system, using rational tissue sampling and cancer genomics as the basis for data generation. We integrate the data we generate in the lab with mathematical and computational models of tumour evolution, with the aim of formulating clinically-driven hypotheses and test predictions that will impact the way we treat cancer.

For this position, we are seeking a highly motivated Higher Scientific Officer / Scientific Officer with expertise in next generation sequencing and cancer biology. The successful candidate will be responsible for different laboratory activities, helping postdocs and students with sample processing, tissue culture, nucleic acid extraction and NGS library preparation. The candidate must have a solid molecular biology background, experience with cancer genomic approaches and be highly organized and meticulous. The successful candidate will work closely with a diverse team to formulate and validate hypotheses.

Applicants should have a good first degree in biological sciences or equivalent, solid experience in genomics, in particular library preparation for next-generation sequencing approaches, as well as general molecular biology techniques including PCR, nucleic acid extraction and cell culture. Experience in digital droplet PCR, immunohistochemistry, flow cytometry, cryosectioning and macro-dissection of tumor specimens are highly desirable. Familiarity with computational biology approaches would be advantageous. Excellent organizational and communication skills are essential.

The position is offered on a 3 year fixed term contract. The salary for the post will be dependent on candidate skills and experience, for Scientific Officer being £26,000 to £33,600 and for Higher Scientific Officer being £32,000 to £44,400.

Informal enquiries can be made to Dr Andrea Sottoriva (andrea.sottoriva@icr.ac.uk). Please DO NOT send your application via email, formal applications must be submitted by applying below.

To apply please upload your CV and covering letter (addressing where you meet the person specification and incl. the names and addresses of two referees)