Higher Scientific Officer / Scientific Officer in Tumour Heterogeneity

02/02/2020, 23:55

Molecular Pathology
Evolutionary Genomics & Modelling
Full time
Fixed Term
3 Years
£32,000 to £44,400 Higher Scientific Officer / £26,000 to £33,600 Scientific Officer
The Institute of Cancer Research, London, is one of the world’s most influential cancer research institutes, with an outstanding record of achievement dating back more than 100 years. We provided the first convincing evidence that DNA damage is the basic cause of cancer, laying the foundation for the now universally accepted idea that cancer is a genetic disease. Today, The Institute of Cancer Research (ICR) leads the world at isolating cancer-related genes and discovering new targeted drugs for personalised cancer treatment.

Under the leadership of our Chief Executive, Professor Paul Workman FRS, the ICR is ranked as the UK’s leading academic research centre. Together with our partner The Royal Marsden, we are rated in the top five cancer centres globally.

The ICR is committed to attracting, developing and retaining the best minds in the world to join us in our mission – to make the discoveries that defeat cancer.

The new Centre for Evolution and Cancer within the Institute of Cancer Research is supported by a Strategic Award from the Wellcome Trust. We focus on interrogating clonal evolution in tumours by studying the dynamics of heterogeneous cancer cell populations and their microenvironment. We make use of multi-region genomic profiling, single-cell genetics, computational histopathological analysis and mathematical modelling to reconstruct the past evolutionary history of tumours and predict their future.

Prof Andrea Sottoriva is the Deputy Director of the Centre for Evolution and Cancer and his lab focuses on deciphering the dynamics of cancer growth, progression and treatment resistance in each patient using a combination of cancer genomic approaches, experimental model systems and mathematical analyses, with the objective of anticipating the future course of the disease.

We tackle cancer as a complex system, using rational tissue sampling and cancer genomics as the basis for data generation. We integrate the data we generate in the lab with mathematical and computational models of tumour evolution, with the aim of formulating clinically-driven hypotheses and test predictions that will impact the way we treat cancer.

For this position, we are seeking a highly motivated Higher Scientific Officer / Scientific Officer with expertise in next generation sequencing and cancer biology. The successful candidate will be responsible for different laboratory activities, helping postdocs and students with sample processing, tissue culture, nucleic acid extraction and NGS library preparation. The candidate must have a solid molecular biology background, experience with cancer genomic approaches and be highly organized and meticulous. The successful candidate will work closely with a diverse team to formulate and validate hypotheses.

Applicants should have a good first degree in biological sciences or equivalent, solid experience in genomics, in particular library preparation for next-generation sequencing approaches, as well as general molecular biology techniques including PCR, nucleic acid extraction and cell culture. Experience in digital droplet PCR, immunohistochemistry, flow cytometry, cryosectioning and macro-dissection of tumor specimens are highly desirable. Familiarity with computational biology approaches would be advantageous. Excellent organizational and communication skills are essential.

The position is offered on a 3 year fixed term contract. The salary for the post will be dependent on candidate skills and experience, for Scientific Officer being £26,000 to £33,600 and for Higher Scientific Officer being £32,000 to £44,400.  Appointments are normally made at the start of the range which represents the market rate for the role but consideration will be given to experience and skills. Future progression is based on annual performance review.

Informal enquiries can be made to Dr Andrea Sottoriva (andrea.sottoriva@icr.ac.uk). Please DO NOT send your application via email, formal applications must be submitted by applying below. 

To apply please upload your CV and complete an online application form addressing in the Supporting Statement section how you meet the person specification and including  the names and addresses of two referees.

We consider all applications on merit and have a strong commitment to enhancing the diversity of our staff.
Additional Documentation for Candidates

This Program is closed to applications.