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Higher Scientific Officer - Target Validation

26/07/2018, 23:55

Sutton
Cancer Therapeutics
Translational Cancer Discovery
Full time
Fixed Term
36 months
35
Salary: £32,145 - £40,018
The Institute of Cancer Research, London, is one of the world’s most influential cancer research institutes, with an outstanding record of achievement dating back more than 100 years. We provided the first convincing evidence that DNA damage is the basic cause of cancer, laying the foundation for the now universally accepted idea that cancer is a genetic disease. Today, The Institute of Cancer Research (ICR) leads the world at isolating cancer-related genes and discovering new targeted drugs for personalised cancer treatment.

Under the leadership of our Chief Executive, Professor Paul Workman FRS, the ICR is ranked as the UK’s leading academic research centre. Together with our partner The Royal Marsden, we are rated in the top four cancer centres globally.

The ICR is committed to attracting, developing and retaining the best minds in the world to join us in our mission – to make the discoveries that defeat cancer.

The Cancer Research UK Cancer Therapeutics Unit, within the Division of Cancer Therapeutics, is a multidisciplinary 'bench to bedside' centre, comprising around 160 staff dedicated to the discovery and development of novel therapeutics for the treatment of cancer. The Cancer Therapeutics Unit’s exciting goal is to discover high quality drug candidates for validated biological targets and to progress these candidates to clinical trial. All the scientific disciplines are in place to make this possible. Our biologists work alongside world-class chemists and drug metabolism specialists focusing on new molecular targets emerging from human genome and ground breaking cell biology research. This is an exciting and fast moving area of cancer research, and offers the opportunity to work within a multi-disciplinary environment using state-of-the-art techniques and equipment. This Unit is now under the leadership of Professor Rajesh Chopra who has previously held senior leadership positions at AstraZeneca and Celgene and academic positions in the UK in haematological oncology and stem cell transplantation.

 We are seeking a talented and highly motivated cell biologist to work in the Cancer Therapeutics Unit, located in well-equipped laboratories in Sutton, South London. The successful applicant will initially work in the translational cancer discovery team led by Prof Raj Chopra. She/he will use advanced molecular and cellular biology techniques including RNAi and CRISPR/cas9 technologies to validate novel molecular targets and characterise the molecular predictors of response to target modulation. Candidates should possess a PhD in Molecular Biology or Cell Biology or have a thorough experience in these areas. The successful applicant will be able to work in an interdisciplinary environment towards the goal of progressing novel cancer therapies by performing robust cellular studies to validate early-stage candidate targets. Knowledge of cancer research and familiarity with contemporary approaches to drug discovery and molecular target validation is essential. Experience in Immunology is highly desirable.

 Starting salary in the region of £32,628 to £40,619 pa inclusive (based on previous experience). Appointment will be for 36 months in the first instance. Further information can be found in the full job description at www.icr.ac.uk.

We consider all applications on merit and have a strong commitment to enhancing the diversity of our staff.
Cancer Research UK
Additional Documentation for Candidates