Post-Doctoral Training Fellow - Genome Stability Team

22/02/2019, 23:55

Cancer Biology
Epigenetics and Genome Stability
Full time
Fixed Term
2 years
35 hours
£31,023 -39,473
The Institute of Cancer Research, London, is one of the world’s most influential cancer research institutes, with an outstanding record of achievement dating back more than 100 years. We provided the first convincing evidence that DNA damage is the basic cause of cancer, laying the foundation for the now universally accepted idea that cancer is a genetic disease. Today, The Institute of Cancer Research (ICR) leads the world at isolating cancer-related genes and discovering new targeted drugs for personalised cancer treatment.

Under the leadership of our Chief Executive, Professor Paul Workman FRS, the ICR is ranked as the UK’s leading academic research centre. Together with our partner The Royal Marsden, we are rated in the top four cancer centres globally.

The ICR is committed to attracting, developing and retaining the best minds in the world to join us in our mission – to make the discoveries that defeat cancer.

The Cancer Research UK Cancer Therapeutics Unit (CTU) within Division of Cancer Therapeutics is ranked among the world’s best academic cancer drug discovery and development groups. Led by Professor Raj Chopra, CTU is a multidisciplinary 'bench to bedside' centre, comprising around 170 staff dedicated to the discovery and development of novel therapeutics for the treatment of cancer. Its 12 research teams cover every aspect of new drug discovery and development, from cell and molecular biology through to chemical synthesis of new agents and their evaluation in clinical trials.

The Genome Stability Team, led by Professor Jessica Downs is investigating the interplay between epigenetics and genome stability. The goal of this research is to understand how the packaging and organisation of DNA in cells helps to maintain its integrity and prevent tumourigenesis.


A Postdoctoral Training Fellow position to work jointly between the CTU and the Genome Stability Team is available to investigate the genetic relationships between chromatin modifying enzymes. You will be responsible for generating mammalian cell lines with modifications to the coding sequence of chromatin modifiers and will use a combination of approaches, including cell and molecular biology-based assays, to investigate the genetic relationships between chromatin modifying enzymes and their impact on cellular fitness.


You will have the opportunity to interact within a multidisciplinary environment of molecular biologists, clinicians, chemists, computer scientists and mathematicians. You will have opportunities to learn about the latest approaches in genetic engineering and will explore new research areas in medicine. Furthermore, this position offers a unique opportunity to gain exposure to cancer drug discovery.


You should possess a PhD in a biological science such as cell biology or biochemistry. Experience with genetic engineering of mammalian cells is essential. Experience in chromatin biology and/or genome instability is desirable.


Appointment will be on a Fixed Term Contract for 2 years.


Informal enquires can be made to Professor Jessica Downs at or Professor Raj Chopra at Please do not send your application to Professors Downs or Chopra, formal applications must be submitted online.

We consider all applications on merit and have a strong commitment to enhancing the diversity of our staff.
Additional Documentation for Candidates

This Program is closed to applications.