Postdoctoral Training Fellows - Protein Crystallography (Two Positions)

10/03/2019, 23:55

Sutton and London
Cancer Therapeutics
Hit Discovery & Structural Design
Full time
Fixed Term
One position is funded for 1 year and one position is funded for 2 years
£31,023 - £39,473 per annum
The Institute of Cancer Research, London, is one of the world’s most influential cancer research institutes, with an outstanding record of achievement dating back more than 100 years. We provided the first convincing evidence that DNA damage is the basic cause of cancer, laying the foundation for the now universally accepted idea that cancer is a genetic disease. Today, The Institute of Cancer Research (ICR) leads the world at isolating cancer-related genes and discovering new targeted drugs for personalised cancer treatment.

Under the leadership of our Chief Executive, Professor Paul Workman FRS, the ICR is ranked as the UK’s leading academic research centre. Together with our partner The Royal Marsden, we are rated in the top four cancer centres globally.

The ICR is committed to attracting, developing and retaining the best minds in the world to join us in our mission – to make the discoveries that defeat cancer.

The Cancer Research UK Cancer Therapeutics Unit (CTU), within the Division of Cancer Therapeutics, is a multidisciplinary 'bench to bedside' centre, comprising around 160 staff dedicated to the discovery and development of novel therapeutics for the treatment of cancer. The CTU’s exciting goal is to discover high quality small molecule drug candidates and to progress these to clinical trial. All the scientific disciplines are in place to make this possible, including medicinal chemistry, biology, structural biology, assay scientists, drug metabolism and clinical specialists. 

Two postdoctoral positions are available in Dr Rob van Montfort’s Hit Discovery and Structural Design Team within the CTU.
The postdoctoral training fellows will be involved in X-ray crystallography, fragment-based screening and structure-based drug design and will be responsible for protein expression, purification, crystallisation, structure determination and structural analysis of protein-ligand complexes from one of the CTU’s drug discovery programmes. The successful candidates will also be part of the Division of Structural Biology, in which the crystallographers in Dr van Montfort’s team are embedded, and will have access to state of the art crystallisation facilities, in-house X-ray sources and excellent access to synchrotrons. They will interact closely with the biology, computational chemistry and medicinal chemistry teams at the CTU, and will therefore be expected to work across the two sites in Chelsea, London and Sutton, Surrey. 

Applicants must have a PhD in a biological or physical science, and experience in macromolecular crystallography (to include protein biochemistry, protein crystallisation and protein crystallography).

Experience in molecular biology, protein expression in insect cells, structure-based drug design, and/or biophysics will be an advantage. 

The starting salary for the positions will be in the range £31,023 to £39,473 p.a. inclusive (based on previous post-doctoral experience).

There are two posts. One is funded for one year and one is funded for two years. Applicants will automatically be considered for both positions.

Informal enquiries can be made via email to or

Please DO NOT send your application to Dr van Montfort or Dr Le Bihan.
Applications will only be considered if made via 
the e-recruitment system, accessed by clicking on the Apply button.

We consider all applications on merit and have a strong commitment to enhancing the diversity of our staff.
Cancer Research UK
Additional Documentation for Candidates

This Program is closed to applications.