Higher Scientific Officer - Breast Cancer Research

27/01/2019, 23:55

London
Breast Cancer Research
Functional Genomics
Full time
Fixed Term
2 years
35
£32,955 to £35,644
The Institute of Cancer Research, London, is one of the world’s most influential cancer research institutes, with an outstanding record of achievement dating back more than 100 years. We provided the first convincing evidence that DNA damage is the basic cause of cancer, laying the foundation for the now universally accepted idea that cancer is a genetic disease. Today, The Institute of Cancer Research (ICR) leads the world at isolating cancer-related genes and discovering new targeted drugs for personalised cancer treatment.

Under the leadership of our Chief Executive, Professor Paul Workman FRS, the ICR is ranked as the UK’s leading academic research centre. Together with our partner The Royal Marsden, we are rated in the top four cancer centres globally.

The ICR is committed to attracting, developing and retaining the best minds in the world to join us in our mission – to make the discoveries that defeat cancer.

The Functional Genomics laboratory headed by Dr Rachael Natrajan focuses on understanding the interplay of genetics and microenvironmental changes in the progression of different forms of breast cancer to identify novel drivers and therapeutic targets of the disease in particular through the use of using more complex 3D patient derived models and high-throughput screening approaches. We have made novel advances into the understanding of genomic alterations and their impact on breast cancer in different contexts and how to target these effectively (including Natrajan et al J Pathol 2014 PMID 24395524; Maguire et al 2015 PMID 25424858; Bajrami et al Cancer Res 2014 PMID: 24240700; Natrajan et al PLOS Medicine 2015 PMID: 26881778, Maguire et al 2016 PMID: 27512948; Naidoo et al 2017 MCT PMID:29133620). In addition, we also use barcoding strategies to understand the molecular evolution of breast cancer and response to targeted therapies. We aim to generate pre-clinical information that can inform the design of clinical trials and the identification of novel targets for drug discovery programmes.

We are seeking a highly motivated Higher Scientific Officer who enjoys working in a multidisciplinary environment to provide high-level technical support for a number of projects running in the laboratory. These projects include further laboratory work on targeting novel driver alterations in different breast cancer subtypes, assessment of molecular heterogeneity in drug resistance using barcoding approaches and development and implementation of customised next-generation sequencing assays.

The candidate will benefit from close interactions with the other teams within the Centre (https://www.icr.ac.uk/our-research/research-divisions/division-of-breast-cancer-research) and the ICR.

This position is on a fixed term contract for 2 years.  The salary scale is on the range from £32,955 - £35,644 p.a. inclusive.  Starting salary will be based on previous experience.

For informal enquiries, please contact Dr Rachael Natrajan on rachael.natrajan@icr.ac.uk  Please note - this address is for enquiries only and you should not send your application to this address.

We consider all applications on merit and have a strong commitment to enhancing the diversity of our staff.
Additional Documentation for Candidates