Higher Scientific Officer - Single Cell Sequencing

07/01/2019, 23:55

Molecular Pathology
Evolutionary Genomics & Modelling
Full time
Fixed Term
3 years
The Institute of Cancer Research, London, is one of the world’s most influential cancer research institutes, with an outstanding record of achievement dating back more than 100 years. We provided the first convincing evidence that DNA damage is the basic cause of cancer, laying the foundation for the now universally accepted idea that cancer is a genetic disease. Today, The Institute of Cancer Research (ICR) leads the world at isolating cancer-related genes and discovering new targeted drugs for personalised cancer treatment.

Under the leadership of our Chief Executive, Professor Paul Workman FRS, the ICR is ranked as the UK’s leading academic research centre. Together with our partner The Royal Marsden, we are rated in the top four cancer centres globally.

The ICR is committed to attracting, developing and retaining the best minds in the world to join us in our mission – to make the discoveries that defeat cancer.

The new Centre for Evolution and Cancer within the Institute of Cancer Research is supported by a Strategic Award from the Wellcome Trust. We focus on interrogating clonal evolution in tumours by studying the dynamics of heterogeneous cancer cell populations and their microenvironment. We make use of multi-region genomic profiling, single-cell genetics, computational histopathological analysis and mathematical modelling to reconstruct the past evolutionary history of tumours and predict their future.


Dr Andrea Sottoriva’s lab, in collaboration with the Greaves and Valeri’s labs at the ICR and other research laboratories in the UK and Italy, has been awarded the CRUK Accelerator Award entitled “Single cell cancer evolution in the clinic”.


The aim of the collaboration is to deliver tools and devices that could be promptly implemented in a clinical setting, to pre-emptively intercept treatment resistance in individual cancer patients. The team will combine cancer evolutionary modelling, new single-cell approaches and novel microfluidic devices, as well as new data integration techniques, with the aim of providing a definitive single-cell portrait of tumor cells, before and after treatment.


For this position, we are seeking a highly motivated Higher Scientific Officer with expertise in cancer genomics and single-cell sequencing. The successful candidate will be responsible for the single-cell sequencing equipment within the lab (one 10x Chromium and one CellenONE system). Specifically, the role consists in single-cell isolation from clinical specimens and library preparation for genomic and transcriptomic profiling of single cells. The candidate must have a solid molecular biology background, experience with cancer genomic approaches and be highly organized and meticulous. The successful candidate will work closely with a diverse team to formulate and validate hypotheses.


Applicants should have a good first degree in biological sciences or equivalent, solid experience in genomics, in particular library preparation for next-generation sequencing approaches, as well as general molecular biology techniques including PCR, nucleic acid extraction and cell culture. Experience in digital droplet PCR, immunohistochemistry, flow cytometry, cryosectioning and macro-dissection of tumor specimens are highly desirable. Familiarity with computational biology approaches would be advantageous. Excellent organizational and communication skills are essential.

The position is offered on a 3 year fixed term contract with the possibility to extend to another 2 years. The salary for the post is up to  £41,026 p.a. inclusive.

Informal enquiries can be made to Dr Andrea Sottoriva (andrea.sottoriva@icr.ac.uk). Please DO NOT send your application via email, formal applications must be submitted online.

Previous applicants for this post need not to apply.

We consider all applications on merit and have a strong commitment to enhancing the diversity of our staff.
Additional Documentation for Candidates

This Program is closed to applications.