Postdoctoral Training Fellow - Cryo-Electron Microscopy & Biochemistry

17/03/2019, 23:55

Structural Biology
Structural Biology of Cell Signalling
Full time
Fixed Term
36 months
£31,023 – £ 39,473
The Institute of Cancer Research, London, is one of the world’s most influential cancer research institutes, with an outstanding record of achievement dating back more than 100 years. We provided the first convincing evidence that DNA damage is the basic cause of cancer, laying the foundation for the now universally accepted idea that cancer is a genetic disease. Today, The Institute of Cancer Research (ICR) leads the world at isolating cancer-related genes and discovering new targeted drugs for personalised cancer treatment.

Under the leadership of our Chief Executive, Professor Paul Workman FRS, the ICR is ranked as the UK’s leading academic research centre. Together with our partner The Royal Marsden, we are rated in the top four cancer centres globally.

The ICR is committed to attracting, developing and retaining the best minds in the world to join us in our mission – to make the discoveries that defeat cancer.

Following a Wellcome Trust Investigator Award to Dr Sebastian Guettler, a Postdoctoral Training Fellow position is available from 01 April 2019 in the Structural Biology of Cell Signalling team in the Divisions of Structural and Cancer Biology. Work in the Guettler laboratory centres on the elucidation of signal transduction mechanisms relevant to the function of cancer cells, in particular the Wnt/b-catenin network and telomere homeostasis and their control by poly(ADP-ribosyl)ation. Research by the team combines structural biology, both by X-ray crystallography and cryo-electron microscopy, biochemistry, biophysics and functional studies in mammalian cells. For a research overview, please visit or

We are looking for a highly motivated and creative candidate with a strong interest in the structural and mechanistic characterisation of large multi-protein complexes. Applicants must have a PhD in a biological or physical science, and experience in biochemistry and cryo-electron microscopy

Research in the Division of Structural Biology is aimed at understanding the structural basis for the function and regulation of proteins and protein complexes implicated in cancer. Our research programmes are complemented by close collaborations with other groups elsewhere in the Institute, including groups from the Divisions of Cancer Biology and Cancer Therapeutics, and provide the mechanistic and structural framework for developing new therapeutics targeting cancer. The Division of Structural Biology is well equipped with state-of-the-art in-house X-ray equipment and robotics, computational infrastructure, an in-house electron microscopy facility (including a high-end 200 keV microscope equipped with a direct electron camera and Volta phase plate to be installed in 2019) and has direct access to a 300 keV Krios microscope, as part of the LonCEM consortium. Links with synchrotron radiation sources and the Electron Bio-Imaging Centre (eBIC) for cryo-electron microscopy are established.

The starting salary for the position will be in the range £31,023 to £ 39,473 p.a. inclusive (based on prior post-doctoral experience). The appointment will be made on a fixed term contract of 36 months in the first instance. Informal enquiries to 

Please DO NOT send your application to Sebastian Guettler, but apply via the e-recruitment system on our website Please attach  your CV and complete a statement section on the application form  explaining how you meet person specification criteria.

We consider all applications on merit and have a strong commitment to enhancing the diversity of our staff.

Funded by

Additional Documentation for Candidates

This Program is closed to applications.