Scientific Officer - Patient Derived Organoid/3D Cell Culture Facility

03/08/2019, 23:55

Breast Cancer Research
Directorate Breast Cancer Research
Full time
Fixed Term
3 years in the first instance
£25,911 - £27,864
The Institute of Cancer Research, London, is one of the world’s most influential cancer research institutes, with an outstanding record of achievement dating back more than 100 years. We provided the first convincing evidence that DNA damage is the basic cause of cancer, laying the foundation for the now universally accepted idea that cancer is a genetic disease. Today, The Institute of Cancer Research (ICR) leads the world at isolating cancer-related genes and discovering new targeted drugs for personalised cancer treatment.

Under the leadership of our Chief Executive, Professor Paul Workman FRS, the ICR is ranked as the UK’s leading academic research centre. Together with our partner The Royal Marsden, we are rated in the top five cancer centres globally.

The ICR is committed to attracting, developing and retaining the best minds in the world to join us in our mission – to make the discoveries that defeat cancer.

A position is available for a Scientific Officer (SO) in the patient-derived models (PDM) team lead by Dr Rebecca Marlow (Liaison Staff Scientist) within the Breast Cancer Now Research Centre (BCNRC). Part of the PDM team is the 3D Facility, which provides expertise and supports experiment design for the Centre, to enable PDO models to be utilized with the aim of growing patient derived tumour tissue for translational studies. 3D cell culture and high content imaging allows for an ex vivo approach to acquire a multi-parametric quantitative description of an in vitro 3D tumour phenotype. The PDM team also has developed a large panel of patient-derived xenograft (PDX) experimental models of breast cancer, with the aim of identifying and characterising targets and associated biomarkers for breast cancer treatment.

We are seeking an individual to join the BCNRC 3D Facility to utilise 3D models. He/she will work under the supervision of Dr Eleanor Knight, who currently is running and managing the 3D facility, and will assist with developing, optimizing and carrying out complex 3D cell culture experiments with group members within the Centre.

The 3D Facility team members also work closely with the in vivo team to enable establishment of PDO models from patient-derived xenograft (PDX) models. The post will be based in the ICR, Chelsea. On occasion, appointed candidate will also interact with Professor Tutt’s laboratory at King’s College London (KCL).

Applicants should have a BSc in biological sciences and previous experience in primary cell culture, and/or methods of 3D cell culture as well as general molecular biology, biochemical, flow cytometry and immunohistochemical techniques. Knowledge of breast cancer cell line models is advantageous. The post-holder will demonstrate good interpersonal skills and collaborative working practices. Excellent organizational and communication skills are essential.

Appointment will be on a Fixed Term Contract for 3 years in the first instance, with a salary in the range of £25.911 - £27,864 inclusive based on relevance of skills and experience.

Informal enquiries are welcome and can be made to Dr. Rebecca Marlow ( Please note that this email address is for enquiries only and you should not send your application to this email. CV and covering letter should be submitted online.

We consider all applications on merit and have a strong commitment to enhancing the diversity of our staff.

Funded by

Breast Cancer Now
Additional Documentation for Candidates

This Program is closed to applications.