Postdoctoral Training Fellow - Cell Biology and Biochemistry of Telomere Function

25/08/2019, 23:55

London
Structural Biology
Structural Biology of Cell Signalling
Full time
Fixed Term
3 years
35
£35,461 - £39,473
The Institute of Cancer Research, London, is one of the world’s most influential cancer research institutes, with an outstanding record of achievement dating back more than 100 years. We provided the first convincing evidence that DNA damage is the basic cause of cancer, laying the foundation for the now universally accepted idea that cancer is a genetic disease. Today, The Institute of Cancer Research (ICR) leads the world at isolating cancer-related genes and discovering new targeted drugs for personalised cancer treatment.

Under the leadership of our Chief Executive, Professor Paul Workman FRS, the ICR is ranked as the UK’s leading academic research centre. Together with our partner The Royal Marsden, we are rated in the top four cancer centres globally.

The ICR is committed to attracting, developing and retaining the best minds in the world to join us in our mission – to make the discoveries that defeat cancer.

We seek to appoint a Postdoctoral Training Fellow to the research team led by Dr Sebastian Guettler in the Divisions of Structural and Cancer Biology. Work in the Guettler laboratory centres on the elucidation of signal transduction mechanisms relevant to the function of cancer cells, in particular the Wnt/b-catenin network and telomere homeostasis and their control by poly (ADP-ribosyl)ation. We take a multi-disciplinary approach that combines structural biology, both by X-ray crystallography and cryo-electron microscopy, biochemistry, biophysics and functional studies in mammalian cells.

The Wellcome Trust-funded Postdoctoral Training Fellow will analyse the mechanism of telomere protection and homeostatic telomere length regulation using a combination of cell biology, biochemistry and proteomics approaches. The particular focus will be the analysis of the role of poly(ADP-ribosyl)ation (PARylation) in telomere maintenance.

You should possess a PhD in a biological science such as cell/molecular biology or biochemistry  and have experience in recombinant DNA techniques and in cell culture techniques, including cell proliferation and viability assays in response to genetic manipulation. In addition, prior experience in studying genome integrity maintenance mechanisms (e.g., the DNA damage response) or telomere biology is essential. 

Appointment will be on a Fixed Term Contract for 3 years. Starting salary will be based on previous postdoctoral experience. 

Research in the Divisions of Structural Biology and Cancer Biology focuses on the functional, biochemical, and structural characterisation of cellular processes relevant to cancer and cancer therapy.

The Division of Structural Biology has managed facilities for protein production, with expertise in multi-subunit expression (insect cell, yeast and bacterial expression, including a 60-litre fermentor), protein crystallography (crystallisation robots, Bruker Microstar and CCD detector) and cryo-electron microscopy (FEI Tecnai T12 and F20). The installation of a state-of-the-art FEI Glacios/Falcon 3 cryo-electron microscope is currently in progress. Regular access to shared cryo-EM facilities, such as eBIC, is available. Moreover, the Institute of Cancer Research is part of the London Consortium for Cryo-EM, hosting an FEI Titan Krios cryo-electron microscope equipped with a Volta phase plate, a Gatan Bioquantum energy filter and K3 detector (available in 2019). The Division is also well-equipped with instrumentation for biophysical analysis (e.g. ITC, fluorescence, multi-angle light scattering).

The Division of Cancer Biology provides a state-of-the-art infrastructure for mammalian cell culture, light microscopy, mammalian genetics, chemical biology and proteomics.

Informal enquiries can be made to sebastian.guettler@icr.ac.uk. Please do not submit your formal application by email,  applications must be submitted on the ICR Careers portal. Please  complete the  application form, giving specific examples of how you meet the person specification and summarising your research interests and motivation for applying. Please attach CV to your application form.

We consider all applications on merit and have a strong commitment to enhancing the diversity of our staff.
Wellcome
Additional Documentation for Candidates