08/09/2019, 23:55

Breast Cancer Research
Full time
Fixed Term
2 years
Salary is Pay Grade Analytical Scientist 2 which has a salary range of £32,000 rising to £39,000 in the first instance. Progression is determined by annual performance review.
The Institute of Cancer Research, London, is one of the world’s most influential cancer research institutes, with an outstanding record of achievement dating back more than 100 years. We provided the first convincing evidence that DNA damage is the basic cause of cancer, laying the foundation for the now universally accepted idea that cancer is a genetic disease. Today, The Institute of Cancer Research (ICR) leads the world at isolating cancer-related genes and discovering new targeted drugs for personalised cancer treatment.

Under the leadership of our Chief Executive, Professor Paul Workman FRS, the ICR is ranked as the UK’s leading academic research centre. Together with our partner The Royal Marsden, we are rated in the top four cancer centres globally.

The ICR is committed to attracting, developing and retaining the best minds in the world to join us in our mission – to make the discoveries that defeat cancer.

Located at the ICR, The Breast Cancer Now Research Centre is the first centre in the UK entirely devoted to breast cancer research and our goal is to advance research into the causes, diagnosis and treatment of breast cancer. The Centre is Directed by Professor Andrew Tutt and is located in state-of-the-art laboratory space, with excellent core facilities and funding.

We are seeking an analytical scientist with experience in Bioinformatics to contribute to the Breast Cancer Research Bioinformatics group led by Dr. Syed Haider at the Breast Cancer Now Centre (ICR, South Kensington, London) and the Endocrinology group headed by Prof. Mitch Dowsett in the adjacent Ralph Lauren Centre for Breast Cancer Research in the Royal Marsden Hospital (RMH). Our goal is to use cutting-edge data-mining techniques in collaboration with experimental and clinical investigators to identify new molecular markers of resistance to treatment in breast cancer. Resultant markers will be validated by co-investigators at the centre and at the clinical trials unit of the ICR. 

You will work as part of a team of inter-disciplinary data scientists who are experts in NGS-data analysis, machine learning and software development; and therefore offering unique learning opportunities. Your work will initially focus on work led by Professer Dowsett involving analysis of RNA-seq and whole exome sequencing of primary tumor samples from a cutting-edge international and multicentre trial looking at palbociclib and letrozole before breast cancer surgery (PALLET). The goal is to identify genomic and/or transcriptomic features associated with patients that do not achieve complete shutdown of proliferation from pro-operative treatment. Other duties will involve analysis and integration of genome sequencing and CRISPR-Cas9 datasets.

Applicants should hold a degree in a computational subject, have experience in statistical programming and scripting, and must have a basic knowledge of biology. It is essential to hold a post-graduate qualification in bioinformatics/biostatistics/computational biology or have gained significant experience within bioinformatics/biostatistics role/s. This position will be offered on a fixed-term for 24 months in the first instance, in line with our current grant end date.

Informal enquiries are welcome and can be made to Dr Syed Haider ( or Prof. Mitch Dowsett ( Please note, this address is for enquiries only and you should not send your application to this email address. Completed application form, CV and covering letter must be submitted online.


We consider all applications on merit and have a strong commitment to enhancing the diversity of our staff.

In partnership with

Breast Cancer NOW
The Royal Marsden NHS Foundation Trust
Additional Documentation for Candidates