Postdoctoral Training Fellow - Protein Crystallography

11/10/2020, 23:55

Sutton and London
Cancer Therapeutics
Hit Discovery & Structural Design
Full time
Fixed Term
1 year
35
£32,844 - £40,902
The Institute of Cancer Research, London, is one of the world’s most influential cancer research institutes, with an outstanding record of achievement dating back more than 100 years. We provided the first convincing evidence that DNA damage is the basic cause of cancer, laying the foundation for the now universally accepted idea that cancer is a genetic disease. Today, The Institute of Cancer Research (ICR) leads the world at isolating cancer-related genes and discovering new targeted drugs for personalised cancer treatment.

Under the leadership of our Chief Executive, Professor Paul Workman FRS, the ICR is ranked as the UK’s leading academic research centre. Together with our partner The Royal Marsden, we are rated in the top five cancer centres globally.

The ICR is committed to attracting, developing and retaining the best minds in the world to join us in our mission – to make the discoveries that defeat cancer.

The Cancer Research UK Cancer Therapeutics Unit (CTU), within the Division of Cancer Therapeutics, is a multidisciplinary 'bench to bedside' centre, comprising around 160 staff dedicated to the discovery and development of novel therapeutics for the treatment of cancer. The CTU’s exciting goal is to discover high quality small molecule drug candidates and to progress these to clinical trial. All the scientific disciplines are in place to make this possible, including medicinal chemistry, biology, structural biology, assay scientists, drug metabolism and clinical specialists.


A postdoctoral position is available in Dr Rob van Montfort’s Hit Discovery and Structural Design Team within the CTU in Sutton. The Post-doc will be involved in X-ray crystallography, fragment-based screening and structure-based drug design and will be responsible for protein expression, purification, crystallisation, structure determination and structural analysis of protein-ligand complexes from one of the CTU’s drug discovery programmes. The successful candidate will also be part of the Division of Structural Biology, located in Chelsea, in which the structural biologists in Dr van Montfort’s team are embedded, and will have access to state-of-the art crystallisation facilities, in-house X-ray sources and excellent access to synchrotrons. The successful candidate will interact closely with the biology, computational chemistry and medicinal chemistry teams at the CTU, and will therefore be expected to work across the two sites in Chelsea, London and Sutton, Surrey.


Applicants must have a PhD in a biological or physical science, and experience in macromolecular crystallography (to include protein biochemistry, protein crystallisation and protein crystallography). Experience in molecular biology, protein expression in insect cells, structure-based drug design, and/or biophysics will be an advantage.


The starting salary for the position will be in the range £32,844 to £40,137 p.a. inclusive (based on previous post-doctoral experience) and the post is offered on a fixed term contract of 1 year. Informal enquiries to rob.vanmontfort@icr.ac.uk or yann-vai.lebihan@icr.ac.uk.



Please DO NOT send your application to Dr van Montfort or Dr Le Bihan, but apply via the e-recruitment system on our website www.icr.ac.uk

 

If you are an EU citizen please see the below link for further information about Brexit:

https://www.gov.uk/settled-status-eu-citizens-families/what-settled-and-presettled-status-means

 

The ICR is the leading academic research centre in the UK. Effective industry collaboration and innovation in new medicines and technologies are at the heart of our approach to drive benefits for patients. The ICR is ranked:

 

  • ·       first for the quality and impact of our research*
  • ·       second worldwide for the number of our publications cited in patents**
  • ·       fourth worldwide for the citation rate of scientific research published across all fields**
  • ·       fourth worldwide for top-cited research publications**
  • ·       in the top five higher education institutions worldwide for academic influence and commercial impact**

 

*2014 Research Excellence Framework

** U-Multirank, 2020


We consider all applications on merit and have a strong commitment to enhancing the diversity of our staff.
Additional Documentation for Candidates