Team Leader in Clonal Evolution in Leukaemias

09/02/2020, 23:55

Full time
Fixed Term
6 years
Starting Salary £61,000
The Institute of Cancer Research, London, is one of the world’s most influential cancer research institutes, with an outstanding record of achievement dating back more than 100 years. We provided the first convincing evidence that DNA damage is the basic cause of cancer, laying the foundation for the now universally accepted idea that cancer is a genetic disease. Today, The Institute of Cancer Research (ICR) leads the world at isolating cancer-related genes and discovering new targeted drugs for personalised cancer treatment.

Under the leadership of our Chief Executive, Professor Paul Workman FRS, the ICR is ranked as the UK’s leading academic research centre. Together with our partner The Royal Marsden, we are rated in the top five cancer centres globally.

The ICR is committed to attracting, developing and retaining the best minds in the world to join us in our mission – to make the discoveries that defeat cancer.

The Centre for Evolution and Cancer within the Institute of Cancer Research is headed by Professor Sir Mel Greaves FRS and supported by a Strategic Award from the Wellcome Trust. The Centre focuses on interrogating clonal evolution in tumours by studying the dynamics of heterogeneous cancer cell populations and their microenvironment. In the Centre, we make use of multi-region genomic profiling, single-cell genetics, computational histopathological analysis and mathematical modelling to reconstruct the past evolutionary history of tumours and predict their future.

We are committed to take on the challenge of cancer’s complexity, evolution and drug resistance through the discovery of innovative new approaches to cancer treatment. We are building a state-of-the-art Centre for Cancer Drug Discovery so we can discover even more innovative cancer drugs that tackle intra-tumour heterogeneity and treatment resistance from the start; we want to build capacity in cancer evolution, and particularly genetic and epigenetic mechanisms driving the evolution of leukemias, to combat cancer’s ability to adapt and evolve.

We are looking for an enthusiastic and motivated researcher to establish an independent research programme focusing on the study of clonal evolution in leukaemias to contribute to the research of the Centre for Evolution and Cancer. This new team will be expected to work in association with Professor Mel Greaves FRS and in collaboration with the other faculty members of the Centre for Evolution and Cancer.

The appointment may be made at tenure-track equivalent (Career Development Faculty). Appropriate support (including staff, consumables and equipment) for the successful applicant’s laboratory will be provided.

To apply, please complete your application on our website. Applications must include:

  • Full CV
  • Lists of major publications, achievements, major research grants, distinctions.
  • Publication list
  • Research plan (five to six pages outlining your current research interests and research programme for the next 5 years)
  • Supporting Letter and  the names and contact details of three academic referees
  • 3-5 PDFs of publications which support your research proposal

For informal enquiries, please contact Professor Sir Mel Greaves or Dr Andrea Sottoriva

If you are an EU citizen please see the below link for further information about Brexit:


We consider all applications on merit and have a strong commitment to enhancing the diversity of our staff. We particularly welcome applications from women and people from ethnic minorities, as they are under-represented at the ICR at this level.
Additional Documentation for Candidates

This Program is closed to applications.