Clinical Fellow in Cancer Genetics

29/06/2019, 23:55

Genetics and Epidemiology
Molecular & Population Genetics
Full time
Fixed Term
3 years
35 hours
£35,795 - £45,193
The Institute of Cancer Research, London, is one of the world’s most influential cancer research organisations, with an outstanding record of achievement dating back more than 100 years. We provided the first convincing evidence that DNA damage is the basic cause of cancer, and discovered many of the early chemotherapy drugs. Today, The Institute of Cancer Research (ICR) leads the world at isolating cancer-related genes and discovering new targeted drugs for personalised cancer treatment.

The ICR is ranked as the UK’s leading academic research centre. Our unique partnership with The Royal Marsden and ‘bench-to-bedside’ approach allows us to create and deliver results in a way that other institutions cannot. Together we are rated in the top five cancer centres globally.

The ICR is committed to attracting, developing and retaining the best minds in the world to join us in our mission – to make the discoveries that defeat cancer.

We are seeking a clinical trainee with an exceptional undergraduate and postgraduate record to join us as a Research Fellow. The fellowship will focus on analytical approaches for better interpreting pathogenicity of variants in cancer susceptibility genes, using datasets generated in-house, available through collaborations or that are publically available. This will include sub-projects relating to (i) population genomics approaches (collaborations Public Health England, Ambry Genetics), (ii) 3D protein structure (collaboration Prof Michael Sternburg, Imperial), (iii) quantitative expression analyses (collaboration Ryten, UCL), (iv) quantitation of functional effect in edited cell models (collaboration Adams, Sanger WTI and Shendure, Washington). In addition, the candidate will be closely involved in development and publication of consensus recommendations across these multiple areas of variant classification on behalf of CanVIG-UK (Cancer Variant Interpretation Group UK). 

Whilst existing skills in data analysis, statistics and programming would be an advantage, this is not a requirement and we would offer intensive early in-house and out-of-house training to ensure development of these skills. Furthermore, two bioinformaticians in the Turnbull team (one working on CanVar-UK with particular strength in ML/software engineering and one working for Turnbull for on testicular cancer research with broad skills in statistics and molecular genetics) will have a specific remit to support the learning and development of the post holder. There is a wealth of expertise in bioinformatics, computational biology and statistics within the broader Houlston and Turnbull teams, providing a relaxed and supportive environment for learning.

The post holder will be located at ICR Sutton.

Occasional UK travel may be required, in particular to present work at research and clinical meetings. For the right candidate, we are open to flexible daily/weekly work-patterns including part-time working.

Informal enquiries are welcome and can be made to Professor Clare Turnbull ( Please note – this address is for enquiries only and applications must be submitted via the apply button below.

We consider all applications on merit and have a strong commitment to enhancing the diversity of our staff.

In partnership with

Cancer Research UK
Additional Documentation for Candidates

This Program is closed to applications.